Anthony DeCostanzo Home


Anthony DeCostanzo is currently a Research Scientist at RIKEN in the Laboratory for Neural Circuit Theory where he is modeling brain function. This work has the broad goal of better understanding of how the brain performs complex tasks and the mechanisms of plasticity that underlie learning. Previously he was a Postdoctoral Research Fellow at Columbia University in the Center for Theoretical Neuroscience where, through a combination of quantitative modeling of data and mathematical / theoretical insights his work investigated the function of the hippocampus, an area of the brain responsible for the consolidation of memories. Prior to his postdoctoral research, while a PhD student in Pharmacology at Columbia from 2001 - 2008, he studied how the brain creates memories, and how drugs effect this process, authoring several peer-reviewed scientific papers.  His research has been funded by the National Science Foundation (NSF), The Gatsby Charitable Foundation, and The National Institutes of Health (NIH). 

Anthony worked as an expert researcher in Technology Transfer for Columbia Technology Ventures in 2009 providing advisory research on pharmaceuticals and information technologies, generating reports on market size, competition and commercialization challenges, and making recommendations to Technology Licensing Officers. From 2007 - 2008 Anthony managed a website, authoring numerous articles and a blog on pharmaceuticals for a general audience for, covering clinical trial results, FDA approvals, New Drug Applications (NDAs) and Biologics License Applications (BLAs).


  • 12-Lipoxygenase regulates hippocampal long-term potentiation by modulating L-type Ca2+ channels. Anthony J. DeCostanzo, Iryna Voloshyna, Zev B. Rosen, Steven J. Feinmark, Steven A. Siegelbaum. Journal of Neuroscience, 2010 February 3;30(5):1822-31.
  • Modulation of cyclic nucleotide-regulated HCN channels by PIP(2) and receptors coupled to phospholipase C. Phillip Pian, Annelisa Bucchi, Anthony J. DeCostanzo, Richard B. Robinson, Steven A. Siegelbaum. Springer: Pflugers Archiv European Journal of Physiology. 2007 October;455(1):125-45.
  • Calcium release from presynaptic ryanodine-sensitive stores is required for long-term depression at hippocampal CA3-CA3 pyramidal neuron synapses. Vivek K. Unni, Stanislav S. Zakharenko, Leonard Zablow, Anthony J. DeCostanzo, Steven A. Siegelbaum. Journal of Neuroscience. 2004 October 27;24(43):9612-22.
  • The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor. Anthony J. DeCostanzo, Xi-Ping Huang, Hsien-Yu Wang, Craig C. Malbon, Springer: Naunyn Schmiedebergs Archives of Pharmacology. 2002 May;365(5):341-8.
  • G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway. Tong Liu, Anthony J. DeCostanzo, Xunxian Lu, Hsien-Yu Wang, Sarah Hallagan, Randall T. Moon, Craig C. Malbon. Science. 2001 June 1;292(5522):1718-22.
  • Interaction between transmembrane domains five and six of the alpha-factor receptor. Peter Dube, Anthony J. DeCostanzo, James B. Konopka. Journal of Biological Chemistry. 2000 August 25;275(34):26492-9.